There are plenty of well-known biotech giants that look like solid investments. But targeting smaller and relatively unknown companies in the industry could provide much juicier returns over the long run. Of course, smaller biotechs tend to be riskier investments, so it's important to pick those with excellent prospects.

Let's look at two biotech stocks that aren't among the most prominent names in the sector but are worth investing in nonetheless: Axsome Therapeutics (NASDAQ: AXSM) and CRISPR Therapeutics (NASDAQ: CRSP). 

Thanks to crucial pipeline and regulatory progress, Axsome Therapeutics has outpaced the market over the past year. But there is substantial upside left for the company. You can see that by looking at the opportunity of its two approved medicines: depression treatment Auvelity, and Sunosi, which targets excessive daytime sleepiness in narcolepsy patients.

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Source Fool.com