(NYSE: PFE) celebrates its 175th anniversary this year, so the pharma giant has a long history. But the drugmaker actually jumped into the global spotlight not long ago when it launched its blockbuster coronavirus vaccine, Comirnaty, followed by top-selling COVID treatment Paxlovid. These two products helped Pfizer reach a record $100 billion in annual revenue in 2022.

The past year, though, has been a difficult one for the big pharma company. Demand for coronavirus products has been on the decline, weighing significantly on earnings. That and losses of exclusivity concerning certain big non-COVID products later this decade have hurt investors' appetite for Pfizer stock. The shares dropped 43% in 2023, a year that even CEO Albert Bourla says "was not a good year for us."

The company reported earnings for the fourth quarter and full-year 2023 this week, and though things remain difficult, Pfizer has offered investors some reasons to be optimistic about the future. Is the worst over for Pfizer? Let's find out.

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Source Fool.com