It's hard for me to pick my top favorite in many categories. Whether talking about actors, athletes, songs, singers, movies, or TV shows, I find it difficult to single one out as the best.

This challenge applies to stocks as well. There are quite a few stocks I think will be big long-term winners. What if I had to choose just one to invest $1,000 in right now? It's not an easy decision, but here's why Vertex Pharmaceuticals (NASDAQ: VRTX) is my pick as the best stock.

Warren Buffett once said that rule No. 1 in investing is to "never lose money." He added that the second rule is "don't forget the first rule." Of course, no stock is guaranteed never to lose you money. However, I think Vertex is the kind of safe haven stock that protects you more than most if the stock market falls.

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Source Fool.com