Biotech companies with few products on the market and red ink on the bottom line may not look like the most attractive investments right now. Equity markets are still down substantially year-to-date, and in this environment investors prefer putting their money in safer stocks.

But for those with a long-term mindset -- and above-average risk tolerance -- relatively small but promising biotech stocks can be compelling options to buy and hold. Here are two biotech stocks to consider buying that could make investors richer in time: Axsome Therapeutics (NASDAQ: AXSM) and CRISPR Therapeutics (NASDAQ: CRSP). 

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Source Fool.com