Even as the volatile market continues to deliver highs and lows to investors, that doesn't mean you can't continue to work toward your long-term personal portfolio goals. The types of companies you buy, the length of time for which you hold them, and the way you allocate your investment funds across your portfolio are just a few factors that can affect the performance of your holdings in a wide range of markets. 

All this being said, wonderful companies with strong core businesses in a robust position to deliver growth over a period of years can help to achieve the results you desire. Let's take a look at two remarkable businesses that could multiply an initial investment over the next decade and beyond. 

Vertex Pharmaceuticals (NASDAQ: VRTX) has built a name for itself in the rare disease drug market with its global footprint in the cystic fibrosis treatment space. It's estimated that there are 88,000 people in North America, Europe, and Australia alone that have the genetic disease.

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Source Fool.com