From its inception through the end of 2022, The Bill Melinda Gates Foundation Trust had made total grant payments of about $71.4 billion. One of the reasons the Trust has been able to make such generous donations is because of the successful investments that make up The Bill Melinda Gates Foundation Trust's portfolio, which is valued at about $42 billion.

Main Street investors can take a cue from the trust and find investment ideas that would benefit their own portfolios. Below, two Motley Fool contributors explain why they believe that among the trust's holdings, (NASDAQ: MSFT) and United Parcel Service (NYSE: UPS) are particularly compelling at the moment.

Scott Levine (Microsoft): The bedrock of the Gates Foundation is Microsoft, its largest holding by far. As of the most recent 13F filing, Microsoft represented 34% of the trust's holdings. The next largest position, Berkshire Hathaway, has about a 17% weighting in the trust.

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Source Fool.com