Shares of Annexon (NASDAQ: ANNX) were down more than 57% on Thursday after the company reported mixed results for an eye disease therapy late Wednesday. The clinical-stage healthcare company focuses on complement-mediated autoimmune, neurodegenerative, and ophthalmic diseases. Its stock is down more than 57% so far this year.

Annexon said in a phase 2 study that ANX007, a therapy to treat the eye disease geographic atrophy (GA), improved vision in patients but did not slow the growth of lesions compared to a placebo. GA is a type of age-related macular degeneration (AMD) marked by difficulty seeing in low light and reduced vision sharpness.

The trial included 270 patients, of whom some received doses of ANX007 every month, some received doses of the drug every other month, and some received a placebo every month or every other month. The average age of the patients was 80. The therapy is designed to work by inhibiting the C1q protein that is overexpressed in GA patients. While patients saw improved vision, the primary endpoint of the study was to slow the number of lesions, and the therapy didn't do that in a statistically significant way.

Continue reading

Source Fool.com