News
![IsoEnergy Provides Update on its U.S. Mine Restart Plans with Advancement of the Tony M Mine in Utah: https://www.irw-press.at/prcom/images/messages/2024/73775/ISO_29022024_ENPRcom.002.png](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBNk5FYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--1fe599ddf9dd099ce4fce33db6d78377cf4fd7e6/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/ISO_29022024_ENPRcom.002.png?locale=us)
IsoEnergy Provides Update on its U.S. Mine Restart Plans with Advancement of the Tony M Mine in Utah
Saskatoon, SK, February 29, 2024 – IsoEnergy Ltd. (“IsoEnergy” or the “Company”) (TSXV: ISO; OTCQX: ISENF) - https://www.commodity-tv.com/ondemand/companies/profil/isoenergy-ltd/ - is
![PANW Profits from Pelosi: Former House Speaker’s Recent Trades: https://www.marketbeat.com/logos/articles/med_20240228101745_panw-profits-from-pelosi-learn-the-former-house-sp.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBM1ZFYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--e208b209ebc349ec916e55b76f369c14584af879/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240228101745_panw-profits-from-pelosi-learn-the-former-house-sp.jpg?locale=us)
PANW Profits from Pelosi: Former House Speaker’s Recent Trades
Despite some ethical concerns, U.S. Senate and House of Representatives members frequently buy and sell stocks of publicly traded companies, often with fantastic returns.
Elected officials'
![Ross Stores a Pre-earnings Buy with this Specific Strategy?: https://www.marketbeat.com/logos/articles/med_20240228150000_ross-stores-a-pre-earnings-buy-with-this-specific.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBM1JFYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--02fa5fdea5f94aee6989fc427c83999d462514fb/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240228150000_ross-stores-a-pre-earnings-buy-with-this-specific.jpg?locale=us)
Ross Stores a Pre-earnings Buy with this Specific Strategy?
While our readers will be well used to hearing how the hottest tech stocks are back trading at all-time highs, there are few stocks from the more traditional industries doing the same thing. Take
![Frequentis appoints new Executive Vice President ATM Civil: https://www.irw-press.at/prcom/images/messages/2024/73783/Frequentis_290224_en.001.jpeg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBekJFYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--8ca4e2dccf5d6f04a38c5127024e4d3b1074163a/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/Frequentis_290224_en.001.jpeg?locale=us)
Frequentis appoints new Executive Vice President ATM Civil
Reinhard Grimm will follow Hannu Juurakko who will be retiring
Hannu Juurakko & Reinhard Grimm
Vienna / Austria (29.02.2024)
Effective 1 July 2024 Reinhard Grimm will take over the
![Lighthouse Unlocks the Power of Generative AI with Launch of Smart Summaries for Hotels: https://www.irw-press.at/prcom/images/messages/2024/73776/Lighthouse_290224_ENPRcom.001.png](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBekZFYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--930dcb2f4a6e8eda394b1c8ec4e5028e280037ef/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/Lighthouse_290224_ENPRcom.001.png?locale=us)
Lighthouse Unlocks the Power of Generative AI with Launch of Smart Summaries for Hotels
DENVER, CO / ACCESSWIRE / February 29, 2024 / Lighthouse, the leading commercial platform for the travel & hospitality industry, today announced the launch of Smart Summaries within its
![How to Use Credit Spreads to Make Income from Options: https://www.marketbeat.com/logos/articles/med_20240227115611_option-cs-intc.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBMDVEYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--125964320d0ed1196dad0ea5aacb01b34c2fb5e3/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240227115611_option-cs-intc.jpg?locale=us)
How to Use Credit Spreads to Make Income from Options
If you are bullish on any optionable stock in any stock sector, you can play any number of options trades. The easiest directional strategy is to buy a call option. However, you will fight time
![Cars.com and Carvana Stock Facing Weaker Consumer Sentiment: https://www.marketbeat.com/logos/articles/med_20240228074245_cars.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBeGxEYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--9d09c4d6053880454fd955d85e0915b1c4c5eec0/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240228074245_cars.jpg?locale=us)
Cars.com and Carvana Stock Facing Weaker Consumer Sentiment
Cars.com Inc. (NYSE: CARS) and Carvana Co. (NYSE: CVNA) are two different ways to play the retail automotive market. Both companies are attempting to modernize and digitize the car buying
![District Applies for Additional Mineral Licenses over Alum Shale Energy Metal Targets in Sweden: https://www.irw-press.at/prcom/images/messages/2024/73762/District_Feb282024_Final_EN_PRcom.002.jpeg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBeFpEYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--de0b30385a4c0e20635331b799e9a9024a163272/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/District_Feb282024_Final_EN_PRcom.002.jpeg?locale=us)
District Applies for Additional Mineral Licenses over Alum Shale Energy Metal Targets in Sweden
Vancouver, B.C. – February 28, 2024 – District Metals Corp. (TSX-V: DMX) (OTCQB: DMXCF) (FRA: DFPP); (“District” or the “Company”) is
![Freshpet Stock: Leading the Pack with Solid Earnings Results: https://www.marketbeat.com/logos/articles/med_20240228072450_freshpet-stock-leading-the-pack-with-solid-earning.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBeHBEYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--3cb96d2e8e665108cd02ccfdd75398464b4c8e53/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240228072450_freshpet-stock-leading-the-pack-with-solid-earning.jpg?locale=us)
Freshpet Stock: Leading the Pack with Solid Earnings Results
Freshpet (NASDAQ: FRPT) is a well-known refrigerated pet food products company. Freshpet’s earnings for Q4 2023 and FY 2023 have caught market attention, sending the stock up over 15% . This surge
![Insider selling at JPM: A Closer Look Amidst Historic CEO Sale: https://www.marketbeat.com/logos/articles/med_20240228071044_insider-selling-at-jpm-a-closer-look-amidst-histor.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBeGhEYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--d7d78b2b9b85cb183cb1569a9dce656cb17e14fb/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240228071044_insider-selling-at-jpm-a-closer-look-amidst-histor.jpg?locale=us)
Insider selling at JPM: A Closer Look Amidst Historic CEO Sale
The recent insider selling activity at JPMorgan Chase & Co. (NYSE: JPM), a leading banking and financial institution, has drawn notable attention, with CEO Jamie Dimon making his first-ever stock
![Portofino Updates Argentine Lithium Projects; PDAC Convention Exhibitor : https://www.irw-press.at/prcom/images/messages/2024/73768/POR_280224_ENPRcom.001.png](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBeGREYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--74c482fc9d958bdd7b391db226d275a841546acb/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/POR_280224_ENPRcom.001.png?locale=us)
Portofino Updates Argentine Lithium Projects; PDAC Convention Exhibitor
Vancouver, B.C., February 28, 2024. PORTOFINO RESOURCES INC. (TSX-V: POR) (OTCQB: PFFOF) (FSE: POTA) (“Portofino” or the “Company”) wishes to update its shareholders and investors on current
![Workday Stock Price is Working on a Buy-the-Dip Opportunity: https://www.marketbeat.com/logos/articles/med_20240227131949_chart-wday-2272024ver001.png](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBOU5DYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--c176fc6bafdc48279d7e066b3689cabf81614a91/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240227131949_chart-wday-2272024ver001.png?locale=us)
Workday Stock Price is Working on a Buy-the-Dip Opportunity
Workday, Inc. (NASDAQ: WDAY) issued a lackluster FQ2 report that left the market wishing for more. However, as tepid as the results are, underperformance is relative to analysts' consensus
![Palantir Stock Has It all… Except the Analysts' Support: https://www.marketbeat.com/logos/articles/med_20240227195033_palantir-stock-has-it-all-except-the-analysts-supp.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBOUpDYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--fd0d3e6fcea4e1f6fe16543ffe45030e0c6fd2c7/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240227195033_palantir-stock-has-it-all-except-the-analysts-supp.jpg?locale=us)
Palantir Stock Has It all… Except the Analysts' Support
Palantir Technologies (NYSE: PLTR) stock is gaining traction and may advance another 50% or more in the next few months. The company has a solid product, growing demand, deepening penetration and
![3 wealth-compounding stocks to beat the market this decade: https://www.marketbeat.com/logos/articles/med_20240226123613_3-wealth-compounding-stocks-to-beat-the-market-thi.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBOVJDYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--20cdde00d8a02ae7be0460b271af5aee2d1c60c6/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240226123613_3-wealth-compounding-stocks-to-beat-the-market-thi.jpg?locale=us)
3 wealth-compounding stocks to beat the market this decade
Because the Federal Reserve (the Fed) has announced potential interest rate cuts for this year, an expectation priced in for March is now being pushed as far back as May or June, according to the
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Mawson’s Subsidiary SXG Drills Highest Grades at Apollo
3 new vein sets extend mineralisation a further 150 m east at Sunday Creek
Mineralisation also extended a further 150 m deeper at Apollo
February 28, 2024 – Vancouver, Canada — Mawson
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Autozone stock price is still in the rally zone
Autozone (NYSE: AZO) shares surged following the FQ2 report, confirming the uptrend is intact. Because the news aligns with the outlook for growth and capital returns, the trend will likely
![Westward Gold Outlines 2024 Exploration Goals at Cortez Trend Properties: https://www.irw-press.at/prcom/images/messages/2024/73753/Westward_022724_ENPRcom.002.png](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBOUpCYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--dd77b8a0f9b8d09f7d9b662c1f187bd8b46e0c62/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/Westward_022724_ENPRcom.002.png?locale=us)
Westward Gold Outlines 2024 Exploration Goals at Cortez Trend Properties
Vancouver, British Columbia, February 27, 2024 – Westward Gold Inc. (CSE: WG, OTCQB: WGLIF, FSE: IM50) (“Westward” or the “Company”) is pleased to provide preliminary details surrounding
![2 penny stocks insiders are buying: https://www.marketbeat.com/logos/articles/med_20240226160916_chart-opk-2262024ver001.png](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBOHBCYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--5ecf493e046eb27473cf01d171aad13d9e730c53/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240226160916_chart-opk-2262024ver001.png?locale=us)
2 penny stocks insiders are buying
Penny stocks are riskier than others for many reasons, including profits and liquidity. Penny stocks trade for pennies a share, often at deep discounts to peers, because they haven’t yet generated
![New highs are coming for Lowe’s stock despite mixed results: https://www.marketbeat.com/logos/articles/med_20240227090542_chart-low-2272024ver001.png](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBOGxCYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--3d49b2007714862414652b43b7794729780a6305/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240227090542_chart-low-2272024ver001.png?locale=us)
New highs are coming for Lowe’s stock despite mixed results
At face value, Lowe’s Companies (NYSE: LOW) had a rough Q4 compared to competitor Home Depot, but the details within the report belie that assessment. Comps were weak, but the company is building
![3 lithium stocks to ride a multi-year cycle: https://www.marketbeat.com/logos/articles/med_20240227091730_3-lithium-stocks-to-ride-a-multi-year-cycle.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBNnRCYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--2f12525477da0c6104c882636d3cdc31a5e9f647/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240227091730_3-lithium-stocks-to-ride-a-multi-year-cycle.jpg?locale=us)
3 lithium stocks to ride a multi-year cycle
The world used to run on coal and other types of fuel that powered the different titans of industry. This cycle started with transportation through railways to factories and steel mills that were
![Domino's Q4 2023 report: Hot and fresh or cold and crusty?: https://www.marketbeat.com/logos/articles/med_20240227091533_dominos-q4-2023-report-hot-and-fresh-or-cold-and-c.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBNnBCYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--6de05bfa8a628210b830ea8b9c97e7050ae2fe9c/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240227091533_dominos-q4-2023-report-hot-and-fresh-or-cold-and-c.jpg?locale=us)
Domino's Q4 2023 report: Hot and fresh or cold and crusty?
Domino's Pizza Inc. (NYSE: DPZ) is a globally recognized pizza delivery brand recently gaining noteworthy attention. Domino's financial results for the fourth quarter of 2023 were reported, and
![Goldman upgraded Nvidia stock, one metric says it could go higher: https://www.marketbeat.com/logos/articles/med_20240227091342_goldman-upgraded-nvidia-stock-one-metric-says-it-c.jpg](https://www.sharewise.com/rails/active_storage/representations/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBNmxCYkE9PSIsImV4cCI6bnVsbCwicHVyIjoiYmxvYl9pZCJ9fQ==--c29ec9e3df2fe329a5d8108ea66066084ea9102f/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCam9MY21WemFYcGxTU0lKTXpVd2VBWTZCa1ZVIiwiZXhwIjpudWxsLCJwdXIiOiJ2YXJpYXRpb24ifX0=--aa36f503a05c343bf077379e5dc8bce118d9db18/med_20240227091342_goldman-upgraded-nvidia-stock-one-metric-says-it-c.jpg?locale=us)
Goldman upgraded Nvidia stock, one metric says it could go higher
Today's market seems to be all over the hype stories found in the world of technology stocks. This is especially the case with blowout performances by names like Nvidia Corporation (NASDAQ: NVDA)
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Refined Metals Corp. and Eagle Plains Resources Enter into an Option Agreement for the Dufferin Project in the Athabasca Basin
6,424 hectare Dufferin Project located approximately 130km northwest of the Key Lake Mines, Saskatchewan
Vancouver, British Columbia, February 27, 2024 – Refined Metals Corp. (CSE: RMC;
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Quad/Graphics is a benefactor of the advertising rebound
Quad/Graphics Inc. (NYSE: QUAD) is a global full-service marketing solutions firm for commercial clients in the retail, healthcare, financial services, publishing and consumer packaging
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bluebird bio: How to play LEAPS options for growth and income
Gene-editing is making huge headlines in the medical sector stemming from the first FDA approval for a CRISPR/cas9 treatment for sickle cell disease SCD and TDT from CRISPR Therapeutics AG