EQS-News: First CNS Lymphoma Patient Dosed in Phase I/II PTT101 Study with Yttrium (90Y) Anditixafortide (PentixaTher)
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EQS-News: Eckert Ziegler Strahlen- und Medizintechnik AG
/ Key word(s): Study
Berlin/Würzburg, 22 November 2023. Pentixapharm AG, a developer of innovative radiopharmaceuticals owned by Eckert Ziegler Strahlen- und Medizintechnik AG (ISIN DE0005659700) today has announced that a first patient has been treated in a dose-finding clinical phase I/II study with Yttrium (90Y) anditixafortide (PentixaTher) at the University Hospital in Essen, Germany. This study, PTT101 (ClinicalTrials.Gov ID: NCT06132737), is a prospective, open-label dose-escalation, multicenter study to evaluate the safety, tolerability, biodistribution and efficacy of PentixaTher in patients with CNS lymphoma (cancer affecting the central nervous systems). PentixaTher is targeting the CXCR-4 cytokine receptor which is widely expressed in different cancer indications. Before treatment, patients will be screened with Gallium-68 (68Ga)-based PentixaFor to confirm the presence of the CXCR-4 receptors. If the PET scan turns out to be positive, PentixaTher will be given in various doses to different dose group (in total 9 to 15 patients). The enrollment is planned to last 12 months. “Previous studies have shown that up to 90% of CNS lymphoma patients overexpress the CXCR4 receptor. We therefore hope that the clinical results in CNS lymphomas with Yttrium (90Y) anditixafortide PentixaTher will show similar outstanding effects on tumor growth as we have observed it in other indications like T-cell lymphomas or Multiple Myelomas” commented Dr. Hakim Bouterfa, Chief Medical Officer at Eckert Ziegler, and Member of the Board at Pentixapharm AG. About Eckert Ziegler Your contact:
22.11.2023 CET/CEST Dissemination of a Corporate News, transmitted by EQS News - a service of EQS Group AG. |
| Language: | English |
| Company: | Eckert Ziegler Strahlen- und Medizintechnik AG |
| Robert-Rössle-Str.10 | |
| 13125 Berlin | |
| Germany | |
| Phone: | +49 30 941084-138 |
| Fax: | +49 30 941084-112 |
| E-mail: | [email protected] |
| Internet: | www.ezag.de |
| ISIN: | DE0005659700 |
| WKN: | 565970 |
| Indices: | SDAX, |
| Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange |
| EQS News ID: | 1779779 |
| End of News | EQS News Service |
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1779779 22.11.2023 CET/CEST
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