Spexis' CXCR4 inhibitor balixafortide demonstrates synergistic efficacy in combination with docetaxel in a metastatic prostate cancer preclinical model
Spexis AG
/ Key word(s): Research Update
Allschwil, Switzerland, July 7, 2022 Spexis' CXCR4 inhibitor balixafortide demonstrates synergistic efficacy in combination with docetaxel in a metastatic prostate cancer preclinical model SPEXIS AG (SIX: SPEX), a clinical-stage biopharmaceutical company, today announced that its CXCR4 inhibitor balixafortide demonstrated synergistic efficacy in combination with docetaxel compared to either drug alone in a metastatic prostate cancer preclinical model. Balixafortide is a potent and selective clinical-stage CXCR4 inhibitor. Spexis is currently evaluating various development opportunities for this program, including in hematological and solid tumors, as well as certain rare diseases beyond oncology. In vivo study in collaboration with the University of Michigan The preclinical study of metastatic prostate cancer combining balixafortide (20 mg/kg twice daily in mice, corresponding to a clinically relevant dose) and docetaxel (5 mg/kg once weekly) assessed tumor burden and tumor-induced bone degradation. Overall, results showed superior synergistic efficacy compared to either drug alone. For measuring tumor burden, PC3-luc tumor cells were assessed by bioluminescence imaging, while bone resorption was analyzed by tartrate-resistant acid phosphatase (TRAcP) serum levels. Animals that received treatment had lower TRAcP levels than the vehicle group (p = 0.01). The combination of balixafortide and docetaxel decreased the total tumor burden significantly (p = 0.009). In addition, tumor-induced bone degradation was assessed by radiography and biomarkers. Radiograph imaging of the tibia on the day of study end demonstrated that animals receiving a combination of balixafortide and docetaxel showed less overall bone degradation from PC3-luc tumor cells. Additional studies are in preparation to investigate the anti-metastatic mechanisms of action in more detail. The experiments were performed pursuant to a research collaboration with Professor Evan T. Keller from the University of Michigan. “The decrease we saw in tumor burden with the combination of balixafortide and docetaxel is encouraging because we have chosen rigorous experimental conditions for both compounds to work alone”, said Evan T. Keller, DVM, PhD, Professor of Urology and Pathology, School of Medicine, University of Michigan. “Despite the availability of new treatments for prostate cancer, for patients whose disease has metastasized there remains a need for better treatment options. These data support further evaluation of this combination in this indication.” “These results are encouraging that balixafortide may have significant potential in the treatment of metastatic prostate cancer and other solid tumors. The study reported in this press release is part of our ongoing evaluation of potential indications for the further development of balixafortide. Spexis is evaluating opportunities in solid tumors, hematologic tumor indications and rare diseases such as primary immunodeficiencies (PIDs). We will announce further plans in due course”, added Jeff Wager, M.D., Chairman and Chief Executive Officer of Spexis AG.
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Language: | English |
Company: | Spexis AG |
Hegenheimermattweg 125 | |
4123 Allschwil | |
Switzerland | |
Phone: | +41 61 567 1600 |
Fax: | +41 61 567 1601 |
E-mail: | [email protected] |
Internet: | www.spexisbio.com |
ISIN: | CH0106213793 |
Valor: | SPEX |
Listed: | SIX Swiss Exchange |
EQS News ID: | 1392417 |
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1392417 07.07.2022