Why Acelyrin Stock Plummeted 59% This Week
Shares of Acelyrin (NASDAQ: SLRN) fell 58.5% this week, according to data provided by S&P Global Market Intelligence, after the recently public biopharmaceuticals company announced discouraging results in a clinical trial evaluating the efficacy of its experimental lead drug, izokibep, in treating an inflammatory skin disease.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that causes scarring, abscesses, malodor, and severe pain. HiSCR (Hidradenitis Suppurativa Clinical Response) measures response to treatment in HS, with HiSCR75 and HiSCR100 indicating at least 75% and 100% reductions, respectively, in total abscess and inflammatory nodule count (and with no worsening of symptoms relative to a baseline measurement).
Late Monday, Acelyrin issued a press release stating the primary endpoint of its HiSCR75 at week 16 of a phase 2b/3 trial did not meet statistical significance -- essentially meaning the treatment failed to demonstrate superiority to placebo in reducing symptoms of moderate-to-severe HS. Shares of the biotech stock plummeted more than 50% on Tuesday in response, and closed the trading week at $11.38 per share. The move effectively wiped out all of the company's gains since going public in an upsized IPO at $18 per share in May.
Source Fool.com
